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ACTL8 Knockout Cell Lines

Gene: ACTL8

Official Full Name: actin like 8provided by HGNC

Gene Summary: Involved in epithelial cell differentiation. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in actin filament; stress fiber; and striated muscle thin filament. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00429 ACTL8 Knockout cell line (HCT 116) Human ACTL8 1:2~1:4 Negative Online Inquiry
KO00430 ACTL8 Knockout cell line (A549) Human ACTL8 1:3~1:4 Negative Online Inquiry
KO25737 ACTL8 Knockout cell line (HeLa) Human ACTL8 1:3~1:6 Negative Online Inquiry
KO25738 ACTL8 Knockout cell line (HEK293) Human ACTL8 1:3~1:6 Negative Online Inquiry

Background

ACTL8 Gene Knockout Cell Lines are genetically engineered models designed to specifically inactivate the actin-like 8 (ACTL8) gene, which is involved in various cellular processes including cytoskeletal dynamics, cellular signaling, and gene expression regulation. These cell lines serve as invaluable tools for researchers aiming to explore the physiological roles of ACTL8 and its implications in health and disease.

The knockout mechanism operates through CRISPR-Cas9 technology, which precisely disrupts the ACTL8 gene, enabling the study of resulting phenotypic changes. By eliminating the gene, researchers can assess the effects on cellular morphology, proliferation, migration, and overall cellular behavior, thus providing insights into the gene's biological functions. This targeted approach allows for a clearer understanding of the molecular pathways influenced by ACTL8, making it a powerful system for functional genomics studies.

The scientific importance of ACTL8 Gene Knockout Cell Lines is reflected in their broad applications in both research and clinical settings. They facilitate the investigation of oncogenic pathways, aid in the discovery of potential therapeutic targets, and are pivotal in the study of cytoskeletal contributions to diseases such as cancer and neurodegeneration. Furthermore, these cell lines can be utilized for drug testing and the assessment of therapeutic efficacy in targeted treatments.

What sets ACTL8 Gene Knockout Cell Lines apart from alternative models is their specificity and precision. Unlike conventional knockdown approaches, which may only reduce gene expression, complete knockout ensures a definitive lack of ACTL8 activity, thereby allowing researchers to draw more accurate conclusions regarding gene function. The reproducibility and consistency of results obtained from these cell lines further enhance their utility.

In realization of the value this product provides, researchers and clinicians can effectively deepen their understanding of ACTL8-related mechanisms, leading to potential breakthroughs in therapeutic strategies. By investing in ACTL8 Gene Knockout Cell Lines, users gain access to a robust model pivotal for advancing scientific knowledge.

At [Company Name], we are dedicated to providing high-quality biological products that empower researchers to drive innovation in their fields. Our expertise in genetic engineering ensures that each product is developed for peak performance, reliability, and ease of use, enabling your research to reach its full potential.

Please note that all services are for research use only. Not intended for any clinical use.

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