Gene: ACRBP
Official Full Name: acrosin binding proteinprovided by HGNC
Gene Summary: The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02031 | ACRBP Knockout cell line (HeLa) | Human | ACRBP | 1:3~1:6 | Negative | Online Inquiry |
ACRBP Gene Knockout Cell Lines are genetically engineered cellular models that specifically disable the expression of the ACRBP (Acrosin Binding Protein) gene. This product utilizes CRISPR/Cas9 technology to achieve precise gene disruption, allowing researchers to study the functional role of ACRBP in various biological processes such as cell differentiation, apoptosis, and cancer progression. By providing a complete knockdown of ACRBP, these cell lines serve as valuable tools for elucidating the gene's contributions to cellular functions and for investigating its involvement in disease mechanisms.
The primary function of ACRBP is associated with sperm maturation and fertility, making these knockout cell lines particularly significant for reproductive biology studies. By creating a system that allows the examination of ACRBP deficiency, researchers can gain insights into male fertility issues as well as potential contraceptive methods that might target this gene. In addition, the disruption of ACRBP has been linked to various cancers, providing a model for studying tumor biology, signaling pathways, and potential therapeutic interventions.
What sets ACRBP Gene Knockout Cell Lines apart from other genetic models is their specificity and reliability. While alternative models often carry unintended mutations or may not completely eliminate gene expression, our knockout cell lines are thoroughly validated to ensure complete gene disruption. This specificity significantly enhances experimental outcomes, leading to more accurate and reproducible results.
For researchers and clinicians focused on understanding the genetic and molecular underpinnings of fertility and cancer, ACRBP Gene Knockout Cell Lines are indispensable resources. Their application in translational research can inform the development of novel diagnostics and targeted therapies, making them essential tools in both academic and clinical laboratories.
Our company is committed to advancing scientific discovery through innovative biological products. With extensive expertise in genetic engineering and a strong focus on quality and reliability, we offer ACRBP Gene Knockout Cell Lines as part of our comprehensive portfolio designed to empower researchers in their quest for knowledge and breakthroughs.
Please note that all services are for research use only. Not intended for any clinical use.
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