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ACOT7 Knockout Cell Lines

Gene: ACOT7

Official Full Name: acyl-CoA thioesterase 7provided by HGNC

Gene Summary: This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30971 ACOT7 Knockout cell line (HeLa) Human ACOT7 1:3~1:6 Negative Online Inquiry
KO30972 ACOT7 Knockout cell line (HCT 116) Human ACOT7 1:2~1:4 Negative Online Inquiry
KO30973 ACOT7 Knockout cell line (HEK293) Human ACOT7 1:3~1:6 Negative Online Inquiry
KO30974 ACOT7 Knockout cell line (A549) Human ACOT7 1:3~1:4 Negative Online Inquiry

Background

ACOT7 Gene Knockout Cell Lines are genetically modified cellular models designed to investigate the function and role of the Acyl-CoA thioesterase 7 (ACOT7) enzyme, which is pivotal in regulating fatty acid metabolism and cellular energy homeostasis. These cell lines possess a targeted disruption of the ACOT7 gene, enabling researchers to explore the biochemical pathways in which ACOT7 is involved and to delineate its contributions to lipid metabolism, inflammation, and energy balance within a cell.

The key function of ACOT7 involves hydrolyzing acyl-CoA thioesters, thus modulating the levels of free fatty acids and acetyl-CoA in various metabolic contexts. By utilizing these knockout cell lines, researchers can observe phenotypic outcomes, alterations in metabolic profiling, and responses to cellular stress that highlight the importance of ACOT7 in physiological and pathological conditions. This experimental tool is paramount in the quest to understand metabolic diseases, obesity, and associated disorders.

In scientific research and clinical applications, ACOT7 Gene Knockout Cell Lines provide an invaluable resource for high-throughput screening, drug development, and validating potential therapeutic targets. Unlike traditional wild-type cell lines, these knockout models allow for a more refined investigation of the specific molecular pathways impacted by the absence of ACOT7, offering a clearer picture of its role in disease mechanisms.

The unique advantage of these cell lines lies in their capacity to offer nuanced insights into metabolic regulation that are often obscured in non-modified cell types. Researchers, clinicians, and pharmaceutical companies will benefit from employing ACOT7 knockout models, as they yield reproducible and significant data that can drive both basic research and translational studies.

At [Company Name], we pride ourselves on our depth of expertise in genetic engineering and our commitment to advancing biological research. By providing high-quality, reliable ACOT7 Gene Knockout Cell Lines, we support the scientific community in unraveling the complexities of metabolism and fostering innovative therapeutic strategies.

Please note that all services are for research use only. Not intended for any clinical use.

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