Gene: ACKR3
Official Full Name: atypical chemokine receptor 3provided by HGNC
Gene Summary: This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05784 | ACKR3 Knockout cell line (HeLa) | Human | ACKR3 | 1:3~1:6 | Negative | Online Inquiry |
KO05785 | ACKR3 Knockout cell line (A549) | Human | ACKR3 | 1:3~1:4 | Negative | Online Inquiry |
ACKR3 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of the Atypical Chemokine Receptor 3 (ACKR3) and its role in various physiological and pathological processes. By removing the ACKR3 gene, these knockout cell lines provide a unique tool for researchers to investigate the receptor's involvement in cell signaling pathways, immune responses, and tumor microenvironments.
The key function of ACKR3 Gene Knockout Cell Lines lies in their ability to enable the dissection of ACKR3-related pathways without the confounding influences of the receptor’s normal signaling functions. These cell lines facilitate experiments that can elucidate the mechanisms by which ACKR3 influences chemokine trafficking and immune cell migration, thus providing insights into its potential roles in diseases such as cancer, cardiovascular disorders, and autoimmune diseases. By utilizing these knockout models, researchers can evaluate the involvement of ACKR3 in disease mechanisms, which is essential for developing targeted therapeutic strategies.
In the realm of scientific research and clinical applications, ACKR3 Gene Knockout Cell Lines stand out for their ability to generate clearer data on receptor functions compared to models where this gene is still expressed. When contrasted with conventional models, these knockout lines allow for unprecedented specificity in responses to various chemokines. As a result, researchers can obtain more reliable data, leading to better understanding and potential advancement in the development of ACKR3-targeted drugs.
The unique selling point of our ACKR3 Gene Knockout Cell Lines is their meticulous design and validation, which ensures reliability, reproducibility, and consistency across experiments. Researchers and clinicians benefit from tools that are backed by robust quality control processes and scientific rigor, thereby enhancing their experimental outcomes.
As a company deeply committed to advancing biological research, we possess extensive expertise in creating high-quality gene knockout models. Our offerings are tailored to meet the needs of researchers seeking to explore the depths of cell signaling and receptor biology, ensuring that our products remain at the forefront of scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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