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ACER3 Knockout Cell Lines

Gene: ACER3

Official Full Name: alkaline ceramidase 3provided by HGNC

Gene Summary: Enables N-acylsphingosine amidohydrolase activity; calcium ion binding activity; and zinc ion binding activity. Involved in several processes, including myelination; positive regulation of cell population proliferation; and sphingolipid metabolic process. Located in Golgi membrane and endoplasmic reticulum membrane. Biomarker of hepatocellular carcinoma and metabolic dysfunction-associated steatohepatitis. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04647 ACER3 Knockout cell line (HeLa) Human ACER3 1:3~1:6 Negative Online Inquiry
KO04648 ACER3 Knockout cell line (HCT 116) Human ACER3 1:2~1:4 Negative Online Inquiry
KO04649 ACER3 Knockout cell line (HEK293) Human ACER3 1:3~1:6 Negative Online Inquiry
KO04650 ACER3 Knockout cell line (A549) Human ACER3 1:3~1:4 Negative Online Inquiry

Background

ACER3 Gene Knockout Cell Lines are specialized cellular models designed to facilitate the functional analysis of the ACER3 gene, which encodes an essential enzyme involved in lipid metabolism. By utilizing CRISPR/Cas9 gene-editing technology, these knockout cell lines effectively eliminate the expression of the ACER3 gene, enabling researchers to investigate the gene's role in various biochemical pathways and disease states. This targeted approach not only enhances the specificity of research outcomes but also allows for a clearer understanding of ACER3's physiological functions.

The primary mechanism of the ACER3 Gene Knockout Cell Lines involves the precise alteration of the genomic DNA within the host cells, resulting in the complete loss of ACER3 protein production. This disruption provides a powerful platform for studying the consequences of ACER3 deficiency on cellular processes such as lipid homeostasis, inflammation, and cellular energy metabolism. Researchers can leverage these cell lines to examine disease mechanisms related to metabolic disorders and potential therapeutic targets, significantly contributing to advancements in the fields of biochemistry and pharmacology.

In comparison to other gene knockout models, the ACER3 Gene Knockout Cell Lines offer unique advantages, including a superior genetic background for high reproducibility, customizable strain availability, and ease of integration into existing experimental frameworks. Additionally, they provide a rapid and efficient means to generate insights with less variability, affording researchers greater confidence in their findings.

For researchers and clinicians dedicated to understanding lipid metabolism and its implications for health and disease, ACER3 Gene Knockout Cell Lines represent an invaluable tool. Their capacity to elucidate the biological functions of key metabolic regulators makes them crucial in the pursuit of novel treatments for metabolic syndrome, diabetes, and related conditions.

Our company has established a strong reputation in developing cutting-edge biological reagents, and with our expertise in cell line generation and molecular biology, we are committed to providing high-quality models like the ACER3 Gene Knockout Cell Lines that empower research and enhance scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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