Gene: ABHD17A
Official Full Name: abhydrolase domain containing 17A, depalmitoylaseprovided by HGNC
Gene Summary: Enables palmitoyl-(protein) hydrolase activity. Involved in negative regulation of NLRP3 inflammasome complex assembly; protein depalmitoylation; and protein localization to membrane. Located in endosome membrane; nuclear speck; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO25593 | ABHD17A Knockout cell line (HeLa) | Human | ABHD17A | 1:3~1:6 | Negative | Online Inquiry |
KO25594 | ABHD17A Knockout cell line (HCT 116) | Human | ABHD17A | 1:2~1:4 | Negative | Online Inquiry |
KO25595 | ABHD17A Knockout cell line (HEK293) | Human | ABHD17A | 1:3~1:6 | Negative | Online Inquiry |
KO25596 | ABHD17A Knockout cell line (A549) | Human | ABHD17A | 1:3~1:4 | Negative | Online Inquiry |
ABHD17A Gene Knockout Cell Lines represent a sophisticated tool designed for the exploration of the biological functions of the ABHD17A gene, which encodes an enzyme involved in lipid metabolism. These specialized cell lines are meticulously engineered to contain a targeted knockout of the ABHD17A gene, effectively halting the production of its protein product. This permits researchers to study the downstream effects of ABHD17A absence on various biological processes, particularly in lipid signaling and metabolism.
The key functions of these cell lines hinge on their ability to model the physiological and pathological consequences of ABHD17A deficiency. By leveraging gene knockout technology, researchers can elucidate the role of ABHD17A in specific metabolic pathways, assess its impact on cellular processes such as proliferation, differentiation, and apoptosis, and investigate its involvement in disease mechanisms where lipid dysregulation is implicated, such as obesity, metabolic syndrome, and certain cancers.
The scientific importance of ABHD17A Gene Knockout Cell Lines is underscored by their applications in fundamental research and translational medicine. These cell lines facilitate high-throughput screening for potential therapeutic targets and the evaluation of novel drug candidates aimed at modulating lipid metabolism, providing critical insights into both basic biology and clinical applications.
What sets our ABHD17A Gene Knockout Cell Lines apart from alternative products is the precision of our gene-editing technology, which ensures a complete knockout without off-target effects. Furthermore, our rigorous quality control guarantees consistent performance across batches, allowing for reproducibility in experimental outcomes.
For researchers and clinicians invested in untangling the complexities of lipid metabolism and its associated disorders, these cell lines are invaluable. They provide a robust platform for innovative research, paving the way for breakthroughs in understanding and treating metabolic diseases.
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