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ABHD10 Knockout Cell Lines

Gene: ABHD10

Official Full Name: abhydrolase domain containing 10, depalmitoylaseprovided by HGNC

Gene Summary: This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00416 ABHD10 Knockout cell line (HeLa) Human ABHD10 1:3~1:6 Negative Online Inquiry
KO20079 ABHD10 Knockout cell line (HCT 116) Human ABHD10 1:2~1:4 Negative Online Inquiry
KO20080 ABHD10 Knockout cell line (HEK293) Human ABHD10 1:3~1:6 Negative Online Inquiry
KO20081 ABHD10 Knockout cell line (A549) Human ABHD10 1:3~1:4 Negative Online Inquiry

Background

ABHD10 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the ABHD10 gene, which encodes an enzyme involved in lipid metabolism and signaling pathways. These knockout cell lines are invaluable tools for investigating the biological roles of ABHD10 and its potential implications in various physiological and pathological processes, including cancer metabolism and neurodegenerative diseases.

The primary function of ABHD10 in regulating lipid homeostasis is critical for maintaining cell membrane integrity and influencing various signaling pathways. By utilizing these knockout cell lines, researchers can effectively dissect the enzyme’s role in hydrolyzing specific lipid substrates and assess the downstream effects on cellular metabolism and function. This model allows scientists to explore how the absence of ABHD10 alters cellular responses to stress, inflammation, and apoptosis.

Furthermore, the scientific importance of ABHD10 Gene Knockout Cell Lines lies in their potential applications in both fundamental research and clinical settings. They serve as excellent platforms for pharmacological studies aiming to identify novel therapeutic targets in diseases associated with dysregulated lipid metabolism. Additionally, these cell lines can facilitate translational research by enabling the exploration of ABHD10's role in drug metabolism and resistance.

One of the key advantages of the ABHD10 Gene Knockout Cell Lines is their ability to provide clear, robust data that outperforms traditional methods such as siRNA knockdown. This permanent gene disruption supports long-term studies, allowing researchers to observe chronic effects without the variability associated with transient transfections. Moreover, these knockout lines are rigorously validated for reliability, ensuring consistent performance across multiple experiments.

In conclusion, ABHD10 Gene Knockout Cell Lines represent a significant advancement in cellular research tools, offering researchers and clinicians critical insights into lipid metabolism and its broader implications in health and disease. Our company is committed to providing high-quality biological products and expertise, enabling you to advance your research with confidence and precision.

Please note that all services are for research use only. Not intended for any clinical use.

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