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ABCC10 Knockout Cell Lines

Gene: ABCC10

Official Full Name: ATP binding cassette subfamily C member 10provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO23915 ABCC10 Knockout cell line (HeLa) Human ABCC10 1:3~1:6 Negative Online Inquiry
KO23916 ABCC10 Knockout cell line (HCT 116) Human ABCC10 1:2~1:4 Negative Online Inquiry
KO23917 ABCC10 Knockout cell line (HEK293) Human ABCC10 1:3~1:6 Negative Online Inquiry
KO23918 ABCC10 Knockout cell line (A549) Human ABCC10 1:3~1:4 Negative Online Inquiry

Background

ABCC10 Gene Knockout Cell Lines are specially engineered cellular models that have been developed to study the functional role of the ABCC10 gene, which is part of the ATP-binding cassette (ABC) transporter family. This gene is implicated in various physiological processes, including drug resistance mechanisms in cancer cells, making it a focal point of research in pharmacology and molecular biology.

These cell lines utilize CRISPR-Cas9 technology to precisely knockout the ABCC10 gene, allowing researchers to investigate the effects of its absence on cellular behavior, particularly in response to anticancer treatments. The loss of ABCC10 provides insights into the transport mechanisms of various chemotherapeutic agents, elucidating pathways associated with resistance to drugs commonly used in oncology. As a result, these knockout models play a vital role in advancing our understanding of cancer biology and discovering potential strategies to overcome drug resistance.

The scientific importance of ABCC10 Gene Knockout Cell Lines extends beyond academic research; they also hold significant applications in the pharmaceutical industry. By utilizing these models, researchers can identify and validate drug candidates that effectively circumvent ABCC10-mediated resistance. Compared to alternative models, such as parental cell lines, these knockout variants offer a controlled environment to assess specific gene function without confounding factors.

One of the key advantages of the ABCC10 Gene Knockout Cell Lines is their ability to provide targeted insights into the underlying mechanisms of drug transport and resistance, ultimately facilitating the development of more effective therapies. This specificity makes them an indispensable tool for both researchers and clinicians who are dedicated to advancing cancer treatments.

Our company specializes in high-quality biological products and cutting-edge genetic engineering solutions, ensuring that our ABCC10 Gene Knockout Cell Lines are rigorously validated and designed to meet the needs of researchers and healthcare professionals. By integrating innovative methods with scientific expertise, we aim to support advancements in cancer treatment and drug discovery through our product offerings.

Please note that all services are for research use only. Not intended for any clinical use.

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