ABCB4 Knockout Cell Lines

ABCB4 Gene Knockout Cell Lines are genetically modified cell lines designed to specifically disrupt the function of the ATP-binding cassette sub-family B member 4 (ABCB4) gene, a critical player in lipid transport and cellular homeostasis. The knockout of this gene leads to alterations in the lipid composition of cell membranes, thereby providing researchers with a powerful tool to study the functional implications of ABCB4 deficiency.

These cell lines operate through a homologous recombination strategy that effectively eliminates the expression of the ABCB4 protein, allowing researchers to investigate downstream signaling pathways and physiological consequences associated with diminished ABCB4 function. In particular, the ABCB4 protein is known for its role in the secretion of phospholipids from hepatocytes into bile, making these knockout cell lines invaluable for studying liver physiology and cholesterol metabolism, as well as drug-induced liver injury models.

The scientific importance of ABCB4 Gene Knockout Cell Lines extends to various research and clinical applications, particularly in hepatology and pharmacology. They are essential for elucidating the mechanisms behind liver diseases, drug toxicology, and lipid-related disorders. By utilizing these cell lines, researchers can gain novel insights into the pathophysiology of diseases linked with ABCB4 dysfunction, as well as explore potential therapeutic strategies targeting this crucial regulator.

What sets our ABCB4 Gene Knockout Cell Lines apart from alternative products is the precision of our gene editing technology, ensuring high efficiency and specificity in gene disruption. Additionally, our cell lines come with comprehensive documentation, including characterization data and detailed protocols that facilitate user adoption.

For researchers and clinicians, investing in ABCB4 Gene Knockout Cell Lines means access to a reliable research model, enhanced experimental reproducibility, and ultimately, the advancement of their work in drug development and disease understanding. With years of experience in genetic modification and cell line production, our company is committed to providing high-quality tools that empower scientific discovery and innovation.