Gene: AATK
Official Full Name: apoptosis associated tyrosine kinaseprovided by HGNC
Gene Summary: The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33027 | AATK Knockout cell line (HCT 116) | Human | AATK | 1:2~1:4 | Negative | Online Inquiry |
KO33028 | AATK Knockout cell line (HEK293) | Human | AATK | 1:3~1:6 | Negative | Online Inquiry |
AATK Gene Knockout Cell Lines are a series of genetically engineered cell lines designed to specifically disrupt the function of the AATK gene, a critical component involved in various biological processes including apoptosis and cellular signaling. These cell lines utilize the CRISPR-Cas9 genome editing technology to achieve precise knockout of the target gene, allowing for the study of gene function and disease mechanisms in a controlled environment.
The key function of the AATK Gene Knockout Cell Lines lies in their ability to facilitate in-depth research into the role of the AATK gene in cellular processes. By removing the expression of this gene, researchers can observe changes in cellular behavior, including alterations in growth patterns, response to stressors, and signaling pathways that may be implicated in diseases such as cancer or neurodegenerative disorders. This capability is particularly beneficial in elucidating the pathophysiology of various conditions and evaluating potential therapeutic targets.
In the context of scientific research and clinical applications, these cell lines serve as essential tools in drug discovery, functional genomics, and mechanistic studies. Their use can significantly enhance the understanding of genetic contributions to disease, paving the way for innovative treatment strategies. Moreover, the AATK Gene Knockout Cell Lines have been validated through extensive characterization, providing robust data that add significant value to experimental outcomes.
Compared to traditional gene knockout methods, the CRISPR-Cas9 technology utilized for these cell lines offers unparalleled precision and efficiency, significantly reducing off-target effects and the time required to generate knockout models. This unique selling point makes the AATK Gene Knockout Cell Lines a highly attractive option for researchers seeking reliable and effective tools for genetic manipulation.
The value of these cell lines extends far beyond mere research applications; they represent a landmark advancement in the ability to investigate gene function in real-time and under variable experimental conditions. Researchers and clinicians alike will find these tools indispensable for accelerating their discoveries and enhancing the translational potential of their work.
Our company is dedicated to advancing scientific research through high-quality biological products. We specialize in providing innovative solutions, and our AATK Gene Knockout Cell Lines exemplify our commitment to excellence, rigor, and collaboration in the life sciences field.
Please note that all services are for research use only. Not intended for any clinical use.
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