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AAGAB Knockout Cell Lines

Gene: AAGAB

Official Full Name: alpha and gamma adaptin binding proteinprovided by HGNC

Gene Summary: The protein encoded by this gene interacts with the gamma-adaptin and alpha-adaptin subunits of complexes involved in clathrin-coated vesicle trafficking. Mutations in this gene are associated with type I punctate palmoplantar keratoderma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20099 AAGAB Knockout cell line (HeLa) Human AAGAB 1:3~1:6 Negative Online Inquiry
KO20100 AAGAB Knockout cell line (HCT 116) Human AAGAB 1:2~1:4 Negative Online Inquiry
KO20101 AAGAB Knockout cell line (HEK293) Human AAGAB 1:3~1:6 Negative Online Inquiry
KO20102 AAGAB Knockout cell line (A549) Human AAGAB 1:3~1:4 Negative Online Inquiry

Background

AAGAB Gene Knockout Cell Lines are specialized cellular models developed to study the functions and implications of the AAGAB (ArfGAP with dual BAR domain 1) gene, a significant regulator in various cellular processes including membrane trafficking, cytoskeletal dynamics, and cellular signaling. These engineered cell lines are created using advanced gene-editing technologies such as CRISPR-Cas9, enabling precise alterations in the AAGAB gene to investigate its role in different biological contexts and disease states.

The primary function of these knockout cell lines lies in their ability to facilitate in-depth research into the pathways influenced by AAGAB. By observing the phenotypic changes that occur in the absence of the AAGAB gene, researchers can elucidate its contributions to cell morphology, growth, apoptosis, and more. The mechanisms of these processes offer insights into fundamental cellular biology and had potential implications for understanding pathophysiological conditions such as cancer, neurodegenerative diseases, and metabolic disorders.

In scientific research and clinical settings, AAGAB gene knockout cell lines serve as invaluable tools for identifying potential therapeutic targets and elucidating the molecular underpinnings of diseases. Their utility extends to drug discovery, where they can be employed to assess the efficacy of compounds and understand the molecular mechanisms by which they exert their effects. Formulating conclusions from the research performed on these cell lines can significantly advance the field of molecular biology and medicine.

What sets AAGAB Gene Knockout Cell Lines apart from other genetic models is their specific tailoring for thorough investigations of the AAGAB gene's function, allowing for high specificity and relevance in research outcomes. Additionally, the precision of CRISPR-Cas9 technology used in their creation minimizes off-target effects, offering researchers a reliable platform for their experiments.

Our commitment to advancing biological research is reflected in our expertise and dedication to providing high-quality genetic tools like the AAGAB Gene Knockout Cell Lines. By delivering these specialized products, we empower researchers and clinicians to explore complex biological questions and contribute to groundbreaking discoveries in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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