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AADAC Knockout Cell Lines

Gene: AADAC

Official Full Name: arylacetamide deacetylaseprovided by HGNC

Gene Summary: Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO39156 AADAC Knockout cell line (HCT 116) Human AADAC 1:2~1:4 Negative Online Inquiry
KO39157 AADAC Knockout cell line (A549) Human AADAC 1:3~1:4 Negative Online Inquiry

Background

AADAC Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to study the function of the AADAC gene, which encodes an enzyme involved in the metabolism of various bioactive compounds, including pharmaceutical agents. By employing CRISPR/Cas9 technology, these knockout cell lines allow researchers to investigate the cellular effects and metabolic pathways mediated by AADAC deficiency, providing critical insights into drug metabolism, pharmacogenomics, and toxicity.

The key mechanism of these cell lines lies in their ability to provide a controlled environment where the AADAC gene is effectively silenced. This gene knockout facilitates the examination of downstream biological effects that may arise from altered metabolic processes. Scientists can assess variations in drug response or toxicity in these cell lines, thereby enhancing our understanding of individual differences in drug metabolism and efficacy.

From a scientific standpoint, AADAC Gene Knockout Cell Lines have significant applications in both basic and translational research. They can be utilized in studies focused on drug development, personalized medicine, and identifying potential off-target effects of therapies. Clinically, this product offers a platform for researchers aiming to elucidate the relationship between genetic variability and therapeutic responses, thereby contributing to the advancement of precision medicine.

The distinct advantage of using AADAC Gene Knockout Cell Lines lies in their specific and reliable gene editing capabilities compared to traditional knockout models. They provide a consistent and reproducible tool for researchers who require precise manipulation of gene expression without the confounding variables often present in animal models or less targeted methods.

For researchers and clinicians seeking to expand their understanding of drug metabolism or explore genetic factors influencing therapeutic outcomes, AADAC Gene Knockout Cell Lines represent a valuable resource that accelerates scientific discovery. This product is backed by our company's extensive expertise in genetic engineering and commitment to enhancing research capabilities, ensuring quality and innovation in every offering.

Please note that all services are for research use only. Not intended for any clinical use.

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