Gene: A2M
Official Full Name: alpha-2-macroglobulinprovided by HGNC
Gene Summary: The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO39158 | A2M Knockout cell line (HeLa) | Human | A2M | 1:3~1:6 | Negative | Online Inquiry |
A2M Gene Knockout Cell Lines represent cutting-edge cellular tools designed to facilitate the detailed study of alpha-2-macroglobulin (A2M) and its involvement in various physiological and pathological processes. A2M is a multifunctional protein that plays a critical role in mediating immune responses, modulating inflammation, and regulating protease activity. The A2M Gene Knockout Cell Lines have been engineered through precise CRISPR-Cas9 technology, effectively disrupting the A2M gene, thus enabling researchers to elucidate the specific functions and pathways associated with A2M depletion or absence.
These cell lines allow for the exploration of A2M's role in diverse biological contexts such as cancer progression, neurodegeneration, and tissue repair mechanisms. By studying the functional consequences of A2M knockout, researchers can gain insights into its regulatory functions in plasma protease pathways and the interplay with various cytokines and growth factors. This biological relevance makes the A2M Gene Knockout Cell Lines an invaluable resource in both basic and applied research settings, including drug discovery, biomarker identification, and therapeutic strategy development.
What sets our A2M Gene Knockout Cell Lines apart from existing alternatives is their rigorous validation, including extensive characterization to ensure consistent performance and reproducibility in experiments. Furthermore, they are available in multiple cellular backgrounds to suit different experimental needs, thus enhancing their versatility across various research applications. Researchers and clinicians can rely on these cell lines to provide reliable data that can lead to significant advancements in understanding diseases where A2M is implicated.
In a rapidly evolving field, the expertise of our company is grounded in rigorous scientific principles and a commitment to quality. We offer a comprehensive portfolio of biological products, exemplified by our A2M Gene Knockout Cell Lines, aimed at advancing the frontiers of scientific discovery and clinical research.
Please note that all services are for research use only. Not intended for any clinical use.
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