CD Biosynsis

Pleuromutilin congeners is a broad-spectrum diterpenoid antibiotic produced by Clitopilus passekerianus and related fungi. In order to develop the biotechnology potential of such natural products, it is crucial to fully understand their biosynthetic pathways. Previously, the pathway for biosynthesis of pleuromutilin congeners has been determined (Figure 1). In this article, the author reports two pathways…

Research background Paclitaxel is a well-known anti-tumor natural product. Over the past two decades, an important bottleneck in the early biosynthesis of paclitaxel has been the heterologous expression of cytochrome P450 (including paclitadiene 5) in the biosynthesis pathway α- Hydroxylase (T5 α H) Hybridity of multiple products). These byproducts will metabolize from the precursor taxadien-5…

Sterols have various important physiological functions, and their biosynthesis and function have been fully studied in eukaryotes. However, the synthesis and function of bacterial sterols are relatively poorly explored. There are several bacteria known to produce sterols from scratch, including aerobic methane oxidizing bacteria, floating mold, and various slime bacteria. Unlike eukaryotes, these bacteria mainly…

Raspberry ketone is the main aromatic compound of red raspberry, which has wide applications in cosmetics, food, and medicine. In recent years, raspberry ketone has attracted wide attention as a essence and dietary supplement.   However, the natural abundance of raspberry ketone is low, with only 1-4 milligrams extracted from 1 kilogram of raspberry, making…