Nature Review | Academician Sang Yup Lee: Microorganisms as Green Factories for Food and Cosmetics Production

With the increasing awareness of environmental issues and sustainability, the demand for products such as environmental protection, high-quality food, and cosmetics is also increasing. At this critical moment, microorganisms become potential key players, providing important solutions for these seemingly completely different problems. Microbial Cell Factory: A Wonderful Revolution   The field of systemic metabolic engineering…

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Transforming Escherichia coli to achieve efficient production of 3-hydroxypropionic acid from glycerol

Research background: The use of renewable substrates such as glycerol to produce 3-HP is a promising method. However, the production of 3-HP from glycerol requires vitamin B-12, which hinders its economic feasibility. Research has shown that using glycerol as a substrate β- The alanine pathway can efficiently produce 3-HP. Therefore, a comparison was made between…

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The Rise and Fall of a Wind Moment: The Trillion Journey of Synthetic Biology

/01/Trillion  imagination   The term “synthetic biology” first appeared in the 1970s, until it was redefined by Stanford professor Eric Kool in 2000 by introducing engineering concepts based on genomics and systems biology, marking the emergence of this discipline. Simply put, synthetic biology is the use of engineered organisms such as bacteria to produce various…

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The University of Washington team utilized GPT-4 to reasonably predict engineered yeast production through algorithmic models

Biomanufacturing technology based on synthetic biology can create novel creations in a flexible and diverse manner that have not been before. However, due to the complexity of biological systems, researchers have to rely on repeated experiments to cultivate and screen engineering microorganisms with superior performance. To reduce the number of experiments and improve the efficiency…

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Ginkgo announces Q3 financial report: $55 million recorded, establishing new partnerships with Pfizer and Google

On November 8, 2023 Eastern Time, synthetic biology company Ginkgo Bioworks (NYSE: DNA, hereinafter referred to as Ginkgo) released its financial performance report for the third quarter of 2023. (Source: Company website)   According to the company’s official website, Ginkgo’s total revenue in the third quarter of 2023 was $55 million, down from $66 million…

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The Synthetic Yeast Genome Project has achieved significant breakthroughs, with all synthetic chromosomes completed and over 50% of DNA synthesized

On November 8, 2023, after 15 years, the Synthetic Yeast Genome Project 2.0 (Sc2.0) research team announced a significant milestone: all 16 chromosomes of synthesized yeast, including a newly synthesized tRNA chromosome, have been synthesized, creating a yeast strain containing over 50% synthetic DNA. The relevant achievements have been published in Cell, Molecular Cell, and…

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The world’s first gene editing therapy for sickle cell anemia has been approved in the UK, jointly developed by Vertex and CRISPR

On November 16th local time in the United States, Vertex Pharmaceuticals (Nasdaq: VRTX) and CRISPR Therapeutics (Nasdaq: CRSP) announced that the UK Medicines and Healthcare Products Regulatory Authority (MHRA) has awarded their jointly developed CRISPR gene editing therapy CASGEVY ™ Conditional marketing license for exaagloggene autotemcel for the treatment of sickle cell anemia (SCD) and…

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Effective Degradation of Antibiotics by Laccase Based Self Amplifying Catalytic System for Sustainable Environmental Remediation

The accumulation of antibiotics in agricultural soils poses a potential threat to soil ecosystems and crop growth, ultimately posing a threat to human health. Tetracycline antibiotics (TCs), such as tetracycline (CTC), oxytetracycline (OTC), and tetracycline (TTC), are widely present in soil as antibacterial agents. Generally speaking, tetracycline is difficult to completely metabolize in the body,…

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Multiple aspects of sulfur incorporation into natural product biosynthesis

Sulfur-containing natural products (sulfur-containing NPs) cover almost every type of NP discovered so far. The source of sulfur in peptide NPs is usually composed of cysteine and methionine. Methionine can be directly incorporated into peptide NPs without any modification, such as precarriebowamide (1). The cysteine residues in peptide NPs are typically embedded in intramolecular disulfides,…

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