Recently, Tosin Thompson published a news article on Nature titled “How CRISPR gene editing could help treat Alzheimer’s”. Alzheimer’s disease is the most common form of dementia, affecting over 55 million people worldwide. It is expected that this number will nearly double by 2050. Most research on Alzheimer’s disease is driven by the amyloid protein…
Less than a month after the world’s first approval of CRISPR-Cas9 genome editing therapy, this therapy received a second approval – this time from the United States, due to its strict regulation and lucrative healthcare market. The UK regulatory agency approved this therapy on November 16th, which inactivates a gene as a means of treating…
Researchers at the Max Planck Institute of Land Microbiology have developed a synthetic biochemical cycle that directly converts carbon dioxide into the core acetyl CoA. Researchers are able to implement each of these three cycle modules in Escherichia coli, which represents an important step in achieving the synthesis of carbon dioxide fixation pathways in a…
Engineering proteins that enhance stability are widely used in the development of biological therapies or diagnostic reagents, as well as in other commercial and industrial applications. For this reason, many related experimental and computational methods have been developed, such as directed evolution, rational design, ancestor sequence reconstruction, and molecular dynamics simulation, which stabilize proteins by…
As is well known, microorganisms can produce abundant secondary metabolites and are an important source for drug development. Streptomyces is a star species in the development and research of microbial drugs, and many medical or agricultural antibiotics such as rapamycin (immunosuppressive agent), nystatin (antifungal), avermectin (insecticidal), and azamycin (antibacterial) are produced from Streptomyces. However, the…
Research background: The use of renewable substrates such as glycerol to produce 3-HP is a promising method. However, the production of 3-HP from glycerol requires vitamin B-12, which hinders its economic feasibility. Research has shown that using glycerol as a substrate β- The alanine pathway can efficiently produce 3-HP. Therefore, a comparison was made between…
According to incomplete statistics, there are no less than 150 global cell culture meat companies, most of which choose varieties with high consumption such as chicken and beef. However, there is also a problem. Currently, the cost and selling price of cell culture meat are much higher than the cost of breeding meat, which makes…
High precision bioengineering and synthetic biology require fine-tuning of gene expression at the transcriptional and post transcriptional levels, and gene transcription itself is strictly regulated by promoters and terminators. Promoters include core promoters and distal promoters (Figure 1), which can determine the practice, organization, and cellular level of gene expression. The terminator is inserted into…
Introduction Compared with methods such as chemical synthesis, using engineering microorganisms to produce high value-added products is a very attractive approach. However, when long and complex compound synthesis pathways are introduced into cells, such as isoprene like compounds, cells activate some regulatory mechanisms to respond to changes in the external environment and achieve their…
Research background: Phenylpropanoid compounds such as p-CA are important precursors for the synthesis of various plant secondary metabolites, including stilbenes, flavonoids, and lignans. These compounds have pharmacological significance due to their beneficial health properties. Although it is feasible to extract or chemically synthesize p-coumaric acid from plant raw materials, the use of glucose for…