CD Biosynsis leverages our extensive experience and technological excellence in synthetic biology to help our customers overcome the challenges of traditional protease production to meet the growing demand for proteases in various fields, including the food industry, chemical industry, and pharmaceutical industry. We also support large-scale, high-efficiency protease production to advance the widespread use of proteases in industrial production.
Proteases represent a large group of different hydrolytic enzymes, usually classified by their site of action, enzyme active site structure and specific reaction mechanisms. They have biochemical and/or physiological roles in many aspects of cellular and organismal functions. However, the development of commercial processes for protease production faces many challenges, among which substrate specificity, enzyme stability and enzyme cost are the main issues faced in industry. In addition, most naturally produced protease have many limitations in industrial applications and need to be modified according to the extreme conditions of the industry. Recent advances in synthetic biology have led to breakthroughs in the development of superior protease-producing microorganisms through genetic and metabolic engineering strategies. Synthetic biology provides engineering ideas and capabilities to dramatically improve the biocatalytic efficiency and enzymatic stability of proteases, thus accelerating the industrial realization of biomanufacturing concepts.
Figure 1. A snapshot of synthetic biology tools used for modification of microbial enzymes. (Shukla P., 2019)
CD Biosynsis' advanced synthetic biology platform and extensive expertise allows us to help our customers develop customized and effective strategies to achieve improved production of proteases.
CD Biosynsis offers our expertise and extensive experience in synthetic biology to help our customers develop effective synthetic biology strategies for efficient protease production. Our scientists can develop customized and optimized strategies according to customer requirements for different industrial applications.
Development of Synthetic Biology Chassis for Protease Production
Our advanced technologies and extensive experience allow us to develop effective synthetic biology tools and strategies for the engineering and modification of different types of microorganisms as ideal chassis for the production of different types of proteases. We focus on developing proteases with high stability and catalytic efficiency to meet the needs of industrial applications in various extreme environments. The following are the protease-producing microorganisms including bacteria, fungi, and algae that we are capable of developing into synthetic biology chassis. If you are interested in other microbial strains, please fill out the online inquiry form and tell us more about your project.
|Aspergillus awamori||Aspergillus fumigatus||Aspergillus niger||Aspergillus oryzae||Aspergillus oryzae|
|Aspergillus saitoi||Bacillus clausii||Bacillus licheniformis||Bacillus stearothermophilus||Bacillus subtilis|
|Bacillus subtilis||Clostridium acetobutylicum||Conidiobolus coronatus||Escherichia coli||Exiguobacterium profundum|
|Lactobacillus brevis||Lactobacillus buchneri||Lysinibacillus fusiformis||Streptomyces avermectnus||Shewanella algae|
Overcome Challenges in Proteases Production
We use our powerful synthetic biology technology platform to analyze the binding efficiency of proteases and their substrates through molecular docking and molecular dynamics simulations to develop proteases with high catalytic efficiency.
We can engineer microorganisms by mutagenesis and cloning to improve the function and stability of proteases.
We use strong promoters to increase the yield of proteases, making large-scale production in bioreactors possible and reducing costs.
CD Biosynsis provides customized solutions for synthetic biology-driven protease production to meet a wide range of applications in laboratory and industrial production.
Applications of protease in the medical field
Applications of protease in the laboratory
Applications of protease in the manufacturing industry
As a rapidly growing synthetic biology company, CD Biosynsis is committed to helping our customers meet the growing and evolving demand for industrial enzyme production. All of our deliverables will undergo a rigorous quality testing process to ensure the quality and reliability and can be delivered on time. If you are interested in our services or have any further questions, please do not hesitate to contact us.