CD Biosynsis is committed to helping our customers develop synthetic biology strategies to improve the production of propanediol (PDO), reduce production costs, and accelerate the industrial production of bio-based PDO. Our scientists with expertise in synthetic biology chassis development, metabolic engineering, and fermentation biology have the ability to develop more efficient microbial cell factories that can produce 1,2-PDO or 1,3-PDO from inexpensive feedstocks.
Propanediol (PDO) with the molecular formula C3H8O2 is an important platform chemical and a widely studied value-added product with high industrial demand. Due to the depletion of natural resources and the increase of government regulations, there is an urgent need to make a transition from the chemical synthesis of PDO to more economical and environmentally sustainable bio-based production. However, microbial production of PDO is largely limited by low efficiency and a number of factors hinder the commercialization process. Advances in synthetic biology and metabolic engineering hold promise for overcoming these obstacles. New strategies and tools of synthetic biology offer an attractive and efficient route for PDO production. Industrialization of synthetic biology-driven microbial production process is also an effective way to reduce the cost of PDO production.
Figure 1. Natural (A) and engineered metabolic pathways (B–D) enabling biosynthesis of 1,3-propanediol (PDO). (Frazão C J R, et al., 2019)
Leveraging our powerful synthetic biology platform, CD Biosynsis can provide our customers with custom synthetic biology services to help them develop effective strategies to achieve efficient biosynthesis of propanediol.
CD Biosynsis can develop effective synthetic biology approaches to help our customers achieve efficient PDO production in a wide range of engineered microorganisms. Our scientists have the ability to accelerate the application of microbial chassis and PDO biosynthetic pathways in industrialized manufacturing.
Discovery and Engineering of Microorganisms for PDO Production
We can help discover natural microorganisms with the capability to produce PDO or we can develop engineered microbial strains with high PDO productivity. A collection of microbial strains can be used for PDO production is listed below. If you can't find the strain you are interested in, please fill out the online inquiry form and tell us more about your project.
|Bacteroides ruminicola||Salmonella typhimurium||Klebsiella pneumoniae||Clostridium butyricum||Clostridium pasteurianum|
|Clostridium thermobutyricum||Clostridium sphenoides||Clostridium strain AK-1||Lactobacillus buchneri||Escherichia coli|
|Corynebacterium glutamicum||Synechococcus elongatus PCC 7942||Synechocystis sp. PCC6803||Salmonella typhimurium||Lactobacillus brevis|
|Candida polymorpha||Pichia robertsii||Saccharomyces cerevisiae||Prototheca wickerhamii||Torulopsis famata|
Design and Engineering of Biosynthetic Pathways for PDO Production
Our scientists have been investigating biosynthetic pathways and key enzymes for PDO production such as deoxyhexose pathway, methylglyoxal pathway, lactate pathway, and glycerol disproportionation pathway. We can develop synthetic biology tools and strategies to improve PDO production and reduce costs by enhancing major metabolic pathways, redistributing carbon flux, enhancing substrate utilization, reducing the accumulation of toxic intermediates, and engineering non-natural PDO synthetic pathways. We have the capability to construct cell factories and develop bioprocesses for more-efficient industrial bio-production of PDO.
CD Biosynsis is committed to increasing the production of bio-based PDO using advanced synthetic biology technologies to meet the growing demand in various applications.
As a rapidly growing synthetic biology company, CD Biosynsis is committed to helping our customers meet the growing and evolving demand for bio-based chemical production. All of our deliverables will undergo a rigorous quality testing process to ensure the quality and reliability and can be delivered on time. If you are interested in our services or have any further questions, please do not hesitate to contact us.