CD Biosynsis has the ability to develop successful strategies for engineering and modifying bacterial chassis to help our customers drive synthetic biology downstream applications. We have developed optimized Design-Build-Test-Learn (DBTL) pipelines to integrate the advantages of model and non-model bacteria. Our scientists will work closely with our customers to exploit the full synthetic biology potential of bacteria.
Synthetic biology focuses on the introduction of new functions in chassis organisms that they do not have in their natural environment. Since bacteria have evolved many useful physiological and metabolic properties, they have become the ideal synthetic biology chassis. In the past few years, there has been an unprecedented increase in the number of novel bacterial species that hole the synthetic biology potential. With the development and application of modern biotechnology such as omics and genome engineering, researchers are no longer limited to using bacterial strains isolated from nature, but have achieved the construction of cell factories based on bacterial chassis. The bacterial chassis have been used not only to unravel biological mechanisms, but also to expand applications in a variety of industries, such as medicine, food, materials, agriculture, and energy.
CD Biosynsis is committed to providing our customers with ideal bacterial chassis with desirable properties using top-down and bottom-up strategies. Our experts in bacteria synthetic biology have been working to develop highly efficient strategies for identifying essential and non-essential genes in bacteria, large-scale genome reduction, high-throughput genetic engineering, DNA synthesis and assembly, and automated computational design.
CD Biosynsis applies our considerable experience in synthetic biology to select bacterial species that can be used as chassis to meet expected applications. We have established a library of optimized bacterial chassis covering model and non-model bacteria to guide cell factory design and construction for fundamental research and diverse applications in the biotechnology, pharmacy, and many other fields. We are also working to explore the application potential of extremophilic bacteria such as thermophilic and cryophile bacteria. The following table lists some of the bacterial chassis in our synthetic biology toolbox, which will be updated continuously. Our scientists can help customers construct bacterial chassis using the common developed strains or support them to develop the potential of new strains.
|Bacterial Strains||Characteristics||Examples of Applications|
||Production of chemicals (e.g., butanol, 1,3-propanediol, polyhydroxyalkanoates (PHAs), and fatty acids).|
||Production of recombinant proteins and enzymes (e.g., α‐amylases, β‐glucanases, and laccases).|
||Production of amino acids (e.g., glutamate and lysine).|
||Production of fine chemicals (e.g., chiral amines, 2-quinoxalinecarboxylic acid, rhamnolipids, terpenoids, and polyketides).|
||Production of natural products (e.g., alanine, indole-3-acetic acid, and β-carotene).|
||Production of industrially relevant compounds.|
|Acinetobacter baylyi ADP1||
||Production of tetrapyrrole compounds, triacylglycerol, etc.|
||Produce high-value chemicals and biofuels (e.g., isopropanol, ethanol, and 3-hydroxybutyrate (3-HB)).|
|Lactic Acid Bacteria||
||Production of green chemicals, fuels, and enzymes (e.g., ethanol, bacteriocins, and proteolytic enzymes).|
||Production of value-added biochemicals (e.g., PHA, isopropanol, and acetoin).|
||Production of diverse PHA (e.g., PHB, P34HB, and PHBV).|
||Production of secondary metabolites (e.g., antibiotics).|
||Production of renewably-produced fuels and specialty chemicals (e.g., long-chain alcohols, ethylene, alkanes, hydrogen, and ethanol).|
||Production of natural products (e.g., tetracyclines, β-lactams, aminoglycosides, and macrolides).|
CD Biosynsis has been continuously expanding our synthetic biology toolbox and keeping our knowledge and skills current. We provide full support for our customers' innovations in synthetic biology. If you require any further details, please feel free to contact us and let us know how we can support your new idea or project.